Extravasation of tumour cells
In cancer the blood-borne spread of tumor cells leads to the formation of secondary tumors. The extravasation of tumor cells is a prerequisite step during metastasis.
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Real-time Imaging of Vasculature
The ASET platform can be used to monitor in vivo physiological response in real time.
Watch videoIntravital Imaging of CAM Vasculature
The ASET Platform utilizes a unique animal model and imaging combination to create powerful images and movies of cellular processes. This video shows the movement of blood through the vasculature of the chorioallantoic membrane.
Watch videoTumor Growth and Cell Migration
The ASET Platform can be used to monitor response to treatment at a macro and micro level.
Watch videoTargeting Therapeutics to Tumours
The ability to target a tumour cell to deliver chemotherapeutic agents spares healthy tissues. Here we show the specific targeting of a monoclonal antibody (anti-CD51) to breast cancer cells.
Watch videoVascular Leak - No Treatment
The normal rate of vascular leak of a 70kDa dye particle from the CAM vasculature is seen above. Upper panel is raw data, lower panel is normalized to show dye particles that have leaked into the surrounding tissue from the blood vessels of the CAM.
Watch videoVascular Leak Following VEGF Treatment
The enhanced rate of vascular leak of a 70kDa dye particle from the CAM vasculature after treatment with VEGF - a potent vascular permeability enhancing agent is shown above. Upper panel is raw data, lower panel is normalized to show dye particles that have leaked into the surrounding tissue from the blood vessels of the CAM.
Watch videoVascular Leak Following LPS Treatment
This video shows the movement of two dyes out of blood vessels after LPS treatment. The red dye (158kDa) demonstrates vascular leak while the green dye (2M kDa) highlights areas of damaged vasculature (this is a control that should not leak from healthy vasculature). Left panels show raw data, middle panels show normal data - ie leak and rightmost panels: surface plots showing areas of increased leak.
Watch videoTracking Tumour Cells In Vivo - Normal Movement
Tumour cells are constantly on the move. The ability to track and quantitate this movement is key to describing the efficacy of certain drugs to halt tumor cell migration (metastasis). In this video, tumour cells move about the tumour tissue unchecked.
Watch videoTracking Tumour Cells In Vivo - Treatment Decreases Movement
Tumour cells are constantly on the move. The ability to track and quantitate this movement is key to describing the efficacy of certain drugs to halt tumor cell migration (metastasis). In this video, tumour cells movement has been diminished following treatment with a monoclonal-based therapy.
Watch videoIn the News
April 10, 2012.
Innovascreen publishes study featuring new real-time ASET platform assay
February 15, 2012. ASET platform used in new study to switch therapeutic targets ON and OFF
July 28, 2011. Metastasis study using ASET platform featured on the cover of Laboratory Investigation
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February 15, 2012. ASET platform used in new study to switch therapeutic targets ON and OFF
July 28, 2011. Metastasis study using ASET platform featured on the cover of Laboratory Investigation
